US 11,944,624 B2
Peptide and small molecule agonists of EphA and their uses
Bingcheng Wang, Solon, OH (US); Bin Su, Cleveland, OH (US); and Aaron Petty, Parma, OH (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
Appl. No. 16/628,990
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US)
PCT Filed Jul. 3, 2018, PCT No. PCT/US2018/040715
§ 371(c)(1), (2) Date Jan. 6, 2020,
PCT Pub. No. WO2019/010180, PCT Pub. Date Jan. 10, 2019.
Claims priority of provisional application 62/529,399, filed on Jul. 6, 2017.
Prior Publication US 2020/0222405 A1, Jul. 16, 2020
Int. Cl. C07D 239/95 (2006.01); A61K 31/517 (2006.01); C07D 403/04 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/517 (2013.01) [C07D 403/04 (2013.01); A61K 45/06 (2013.01)] 6 Claims
 
1. A pharmaceutical composition comprising:
a compound having the formula:

OG Complex Work Unit Chemistry
wherein R2 is selected from H, an alkoxy or a C1-6 alkyl group,
Z is selected from the group consisting of

OG Complex Work Unit Chemistry
R7 is selected from H, an alkoxy or a C1-6 alkyl group, and n1 is an integer from 1-20, and pharmaceutically acceptable salts thereof; and
a pharmaceutically acceptable carrier.