US 11,944,596 B2
Enteral feeding devices and related methods of use
Robert Gallotto, Medway, MA (US); Greta L. Loring, Wakefield, MA (US); Kenneth Gary, Boxborough, MA (US); Edward S. Park, Southborough, MA (US); David J. Brown, Brookline, MA (US); Willem Robert Klaas Schoevaart, Delft (NL); and Michiel Christian Alexander van Vliet, Delft (NL)
Assigned to Alcresta Therapeutics, Inc., Waltham, MA (US)
Filed by Alcresta Therapeutics, Inc., Newton, MA (US)
Filed on May 27, 2021, as Appl. No. 17/332,194.
Application 17/332,194 is a continuation of application No. 16/287,543, filed on Feb. 27, 2019, granted, now 11,045,440.
Application 16/287,543 is a continuation of application No. 15/291,530, filed on Oct. 12, 2016, granted, now 10,258,590, issued on Apr. 16, 2019.
Claims priority of provisional application 62/241,608, filed on Oct. 14, 2015.
Prior Publication US 2021/0283085 A1, Sep. 16, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A23L 33/00 (2016.01); A23L 33/12 (2016.01); A61J 15/00 (2006.01); A61K 31/202 (2006.01); A61L 29/04 (2006.01); A61M 5/14 (2006.01); A61M 5/142 (2006.01); C12N 9/20 (2006.01); C12N 11/06 (2006.01); C12N 11/087 (2020.01); C12N 11/089 (2020.01)
CPC A61K 31/202 (2013.01) [A23L 33/00 (2016.08); A23L 33/12 (2016.08); A23L 33/40 (2016.08); A61J 15/0076 (2015.05); A61L 29/048 (2013.01); A61M 5/14 (2013.01); A61M 5/1413 (2013.01); A61M 5/142 (2013.01); C12N 9/20 (2013.01); C12N 11/06 (2013.01); C12N 11/087 (2020.01); C12N 11/089 (2020.01)] 20 Claims
OG exemplary drawing
 
1. A device comprising:
a housing, the housing comprising:
a chamber;
a first opening configured to receive a flow of liquid, wherein the liquid contains fats, wherein the first opening is fluidly connected to the chamber to allow the liquid to flow from the first opening into the chamber;
a second opening, wherein the second opening is fluidly connected to the chamber to allow the liquid to flow out of the chamber and through the second opening; and
a plurality of particles contained within the chamber, wherein lipase is immobilized to the plurality of particles;
wherein the plurality of particles are configured to transition from a dry configuration to a wet configuration when exposed to the liquid;
wherein, in the dry configuration, the plurality of particles have a moisture level of 0.1% to 5%, and wherein, in the wet configuration, the plurality of particles swell in volume by no more than 20% relative to the dry configuration, and
wherein the device is configured to connect to at least one of an enteral feeding tube or a syringe.
 
13. A method of preparing a nutritional formula, the method comprising:
passing a liquid comprising triglycerides through the device of claim 1 to expose the liquid to the lipase to at least partially hydrolyze at least a portion of the triglycerides,
wherein, after exposure to the lipase, the liquid contains less triglycerides and more monoglycerides and free fatty acids than before exposure to the lipase.
 
16. An enteral feeding device comprising:
a housing, the housing comprising:
a chamber;
a first opening, wherein the first opening is fluidly connected to the chamber;
a second opening, wherein the second opening is fluidly connected to the chamber, so that a flow path extends through device through the first opening, through the chamber, and through the second opening; and
a plurality of particles contained within the chamber, wherein lipase is immobilized to the plurality of particles; and
wherein the chamber includes a first portion and a second portion, wherein the first portion is not occupied by the plurality of particles;
wherein the plurality of particles are configured to transition from a dry configuration to a wet configuration when exposed to a liquid, wherein the liquid contains fats; and
wherein, in the dry configuration, the plurality of particles have a moisture level of to 5%, and wherein, in the wet configuration, the plurality of particles swell in volume by no more than 20%.