US 11,944,448 B2
Adaptive illumination apparatus, method, and applications
Chris Xu, Ithaca, NY (US); Kriti Charan, Freeville, NY (US); Bo Li, Ithaca, NY (US); and Michael Buttolph, Ithaca, NY (US)
Assigned to Cornell University, Ithaca, NY (US)
Filed by Cornell University, Ithaca, NY (US)
Filed on Oct. 5, 2022, as Appl. No. 17/960,805.
Application 17/960,805 is a continuation of application No. 16/344,157, granted, now 11,607,165, previously published as PCT/US2017/061801, filed on Nov. 15, 2017.
Claims priority of provisional application 62/422,268, filed on Nov. 15, 2016.
Prior Publication US 2023/0039098 A1, Feb. 9, 2023
Int. Cl. A61B 5/00 (2006.01); G02B 21/00 (2006.01); H01S 3/067 (2006.01)
CPC A61B 5/40 (2013.01) [A61B 5/0071 (2013.01); G02B 21/0032 (2013.01); H01S 3/06754 (2013.01); G01N 2201/0697 (2013.01)] 19 Claims
OG exemplary drawing
 
1. An imaging system for adaptive illumination, comprising:
an excitation source having a modulator, which generates a pulse intensity pattern having a first wavelength when the excitation source receives a modulation pattern comprising a data sequence of at least a portion of a structural image of a sample;
an amplifier configured to receive and amplify the pulse intensity pattern from the modulator;
a frequency shift mechanism which shifts the first wavelength of the pulse intensity pattern to a second wavelength; and
a laser scanning microscope, which receives the pulse intensity pattern having the second wavelength;
wherein at least a portion of the structural image of the sample comprises one or more regions of interest to define the data sequence.