US 12,266,517 B2
Method for evaluating mass spectrometry device, method for calibrating mass spectrometry device, analysis method, mass spectrometry device, and mass spectrometry reagent
Yukihiko Kudo, Kyoto (JP); Kenichi Obayashi, Kyoto (JP); and Katsuhiro Nakagawa, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Appl. No. 17/278,905
Filed by SHIMADZU CORPORATION, Kyoto (JP)
PCT Filed Sep. 28, 2018, PCT No. PCT/JP2018/036545
§ 371(c)(1), (2) Date Mar. 23, 2021,
PCT Pub. No. WO2020/066009, PCT Pub. Date Apr. 2, 2020.
Prior Publication US 2022/0051885 A1, Feb. 17, 2022
Int. Cl. G01N 21/64 (2006.01); B01F 23/00 (2022.01); B01F 23/41 (2022.01); B01F 101/23 (2022.01); B23Q 17/24 (2006.01); C07K 14/705 (2006.01); C12M 1/34 (2006.01); C12Q 1/04 (2006.01); C12Q 1/18 (2006.01); C12Q 1/686 (2018.01); G01N 21/3577 (2014.01); G01N 21/359 (2014.01); G01N 21/39 (2006.01); G01N 21/45 (2006.01); G01N 21/77 (2006.01); G01N 21/78 (2006.01); G01N 27/414 (2006.01); G01N 27/62 (2021.01); G01N 30/12 (2006.01); G01N 30/68 (2006.01); G01N 30/70 (2006.01); G01N 30/72 (2006.01); G01N 30/88 (2006.01); G01N 33/00 (2006.01); G01N 33/18 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01); G01N 33/74 (2006.01); G01N 35/00 (2006.01); G01N 35/10 (2006.01); G06K 7/10 (2006.01); G06K 7/14 (2006.01); G06K 19/06 (2006.01); G06K 19/07 (2006.01); G06T 7/00 (2017.01); G06T 7/90 (2017.01); H01J 49/00 (2006.01); H10K 10/46 (2023.01); H10K 85/00 (2023.01); H10K 85/20 (2023.01)
CPC H01J 49/0009 (2013.01) [G01N 27/62 (2013.01); G01N 30/7206 (2013.01); G01N 30/7233 (2013.01); H01J 49/004 (2013.01)] 14 Claims
OG exemplary drawing
 
13. A method, comprising:
using a mass spectrometry reagent to determine whether or not a mass spectrometry device is in a state suitable for analysis based on a ratio of intensities of a plurality of types of ions produced by dissociation of an ester of phthalic acid obtained by mass spectrometry, the reagent comprising an ester of phthalic acid; and
based on the mass spectrometry device being in a state suitable for analysis, performing analysis with the mass spectrometry device, and based on the mass spectrometry device not being in a state suitable for analysis, causing an output unit to output a notification indicating that the mass spectrometry device is not in a state suitable for analysis, wherein
the mass spectrometry device includes a gas chromatograph and a mass spectrometry unit;
the gas chromatograph includes a carrier gas flow path, a sample of an analysis target, a sample introduction unit into which the sample of analysis target, the first standard substance and the second standard substance are introduced, a column temperature control unit, a separation column and a sample gas introduction tube; and
the mass spectrometry unit includes a vacuum vessel, an evacuation port, an ionization unit, an ion adjustment unit, a mass separation unit, and a detection unit.