	US 12,265,082 B2
	Detecting microbial infection in wounds
Jan Hinrich Guse, Tübingen-Bühl (DE); Martin Reisser, Esslingen (DE); Nikolas Pietrzik, Tübingen (DE); Christiane Baeuerlein, Ofterdingen (DE); and Kornelia Eitel, Tübingen (DE)
Assigned to SYNOVO GMBH, Tübingen (DE)
Filed by SYNOVO GMBH, Tübingen (DE)
Filed on May 4, 2023, as Appl. No. 18/312,017.
Application 18/312,017 is a continuation of application No. 16/090,075, granted, now 11,740,241, previously published as PCT/IB2017/001182, filed on Mar. 30, 2017.
Claims priority of provisional application 62/315,546, filed on Mar. 30, 2016.
Claims priority of provisional application 62/315,556, filed on Mar. 30, 2016.
Prior Publication US 2024/0027454 A1, Jan. 25, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 9/10 (2006.01); G01N 33/548 (2006.01); G01N 33/573 (2006.01); G01N 33/58 (2006.01)

CPC G01N 33/573 (2013.01) [G01N 33/548 (2013.01); G01N 33/582 (2013.01); G01N 33/583 (2013.01); G01N 2333/902 (2013.01); G01N 2333/908 (2013.01); G01N 2333/916 (2013.01); G01N 2333/936 (2013.01); G01N 2333/95 (2013.01); G01N 2333/966 (2013.01); G01N 2400/40 (2013.01); G01N 2800/26 (2013.01)]

26 Claims

1. A chemical entity comprising a compound of Formula I:

A-R-I Formula I

wherein

A is an anchor;

R is an enzyme recognition site; and

I is an indicator region;

wherein the enzyme recognition site (R) comprises at least one enzyme-labile region or enzyme-reactive region; and

wherein the anchor (A) enables binding of the chemical entity to a support material.