US 12,264,966 B2
Fluorescence imaging probe and handheld ImagingProber
Huiming Cai, Nanjing (CN); and Ziyang Wang, Nanjing (CN)
Assigned to NANJING NUOYUAN MEDICAL DEVICES CO., LTD., Nanjing (CN)
Appl. No. 18/562,332
Filed by NANJING NUOYUAN MEDICAL DEVICES CO., LTD., Jiangsu (CN)
PCT Filed Apr. 6, 2023, PCT No. PCT/CN2023/086671
§ 371(c)(1), (2) Date Nov. 20, 2023,
PCT Pub. No. WO2024/077895, PCT Pub. Date Apr. 18, 2024.
Claims priority of application No. 202211256931.9 (CN), filed on Oct. 14, 2022.
Prior Publication US 2024/0272001 A1, Aug. 15, 2024
Int. Cl. G01J 3/44 (2006.01); G01J 3/02 (2006.01); G01J 3/28 (2006.01); G01J 3/12 (2006.01)
CPC G01J 3/4406 (2013.01) [G01J 3/0272 (2013.01); G01J 3/2823 (2013.01); G01J 2003/1213 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A handheld fluorescence imaging probe, wherein the handheld fluorescence imaging probe comprises a dichroic filter and an image detector,
wherein the dichroic filter is arranged at an included angle of 45° with a direction of a main optical axis of an incident excitation light;
the incident excitation light is reflected by the dichroic filter to a target detection position;
the reflected incident excitation light excites a fluorescent substance at the target detection position to form a fluorescence;
a main optical axis of the fluorescence is arranged coaxially with the image detector;
the fluorescence is incident to the image detector through the dichroic filter, and the image detector converts the received fluorescence into an image signal;
wherein the incident excitation light is emitted by a laser device and transmitted to the dichroic filter through an optical fiber, a dodging lens group is further provided at a light emergent side of the optical fiber, the dodging lens group comprises a diverging element and a dodging lens that are arranged in sequence;
wherein the dodging lens is configured to homogenize the diffused incident excitation light, and the diverging element is configured to diffuse a divergence angle of the incident excitation light, such that the diffused divergence angle is slightly larger than a field angle of the image detector;
wherein setting parameters in the dodging lens group satisfy following relationships:

OG Complex Work Unit Math
where u is a distance between a laser light emitting point and the diverging element, v is an image distance of the diverging element, θ0 is a half divergence angle of the incident excitation light at the light emergent side of the optical fiber, θ1 is a half divergence angle of the diverging element, Ø is a diameter of the optical fiber, D is a clear aperture of the diverging element, and d is a distance between the light emergent side of the optical fiber and the diverging element,
wherein a first planar reflecting mirror and a second planar reflecting mirror are provided at intervals in sequence at a light reflecting side of the dichroic filter, wherein the first planar reflecting mirror is perpendicular to the dichroic filter, and the second planar reflecting mirror and the first planar reflecting mirror have a preset included angle therebetween, wherein the preset included angle is 15°-35°, and the incident excitation light reflected by the dichroic filter is reflected sequentially by the first planar reflecting mirror and the second planar reflecting mirror and then is emitted, such that the excitation light is coaxial with a field of view and is emitted obliquely upwards at an included angle of 30°-70° with a horizontal direction.