	US 12,264,347 B2
	Repair of UV-induced DNA lesions
Jeroen Hofenk, Antwerp (BE)
Appl. No. 17/413,792
Filed by ASTERION THERAPEUTICS BVBA, Antwerp (BE)
PCT Filed Dec. 14, 2019, PCT No. PCT/EP2019/085208 § 371(c)(1), (2) Date Jun. 14, 2021, PCT Pub. No. WO2020/120788, PCT Pub. Date Jun. 18, 2020.
Claims priority of application No. 18212780 (EP), filed on Dec. 14, 2018.
Prior Publication US 2022/0017885 A1, Jan. 20, 2022
Int. Cl. C12N 9/88 (2006.01); A61K 8/66 (2006.01); A61K 38/51 (2006.01); A61Q 19/08 (2006.01); C07K 14/47 (2006.01); C12N 15/82 (2006.01)

CPC C12N 9/88 (2013.01) [A61K 8/66 (2013.01); A61K 38/51 (2013.01); A61Q 19/08 (2013.01); C07K 14/47 (2013.01); C12N 15/8257 (2013.01); C12Y 401/99003 (2013.01); C07K 2319/21 (2013.01); C07K 2319/33 (2013.01)]

15 Claims

1. A composition comprising a recombinant enzyme that comprises a fusion of a cyclobutane pyrimidine dimer photolyase corresponding to an amino acid encoding sequence of SEQ ID NO 1,

a pyrimidine(6-4)pyrimidone photolyase corresponding to an amino acid encoding sequence of SEQ ID NO 2, and

a skin penetrating peptide.