US 12,264,338 B2
Paramyxovirus virus-like particles as protein delivery vehicles
Anthony Paul Schmitt, State College, PA (US); Phuong Tieu Schmitt, State College, PA (US); and Greeshma Vivekananda Ray, Cleveland, OH (US)
Assigned to The Penn State Research Foundation, University Park, PA (US)
Filed by The Penn State Research Foundation, University Park, PA (US)
Filed on Apr. 18, 2022, as Appl. No. 17/723,054.
Application 17/723,054 is a continuation of application No. 16/433,412, filed on Jun. 6, 2019, granted, now 11,339,375.
Application 16/433,412 is a continuation of application No. 15/383,324, filed on Dec. 19, 2016, granted, now 10,316,295, issued on Jun. 11, 2019.
Claims priority of provisional application 62/268,921, filed on Dec. 17, 2015.
Prior Publication US 2022/0267740 A1, Aug. 25, 2022
Int. Cl. C12N 7/00 (2006.01); C07K 14/005 (2006.01); C07K 14/81 (2006.01); C07K 16/10 (2006.01); C12N 9/02 (2006.01)
CPC C12N 7/00 (2013.01) [C07K 14/005 (2013.01); C07K 14/8121 (2013.01); C07K 16/1027 (2013.01); C12N 9/0069 (2013.01); C12N 9/0089 (2013.01); C12Y 113/12005 (2013.01); C12Y 115/01001 (2013.01); C12N 2760/18022 (2013.01); C12N 2760/18023 (2013.01); C12N 2760/18034 (2013.01); C12N 2760/18222 (2013.01); C12N 2760/18223 (2013.01); C12N 2760/18234 (2013.01); C12N 2760/18252 (2013.01); C12N 2760/18722 (2013.01); C12N 2760/18723 (2013.01); C12N 2760/18734 (2013.01)] 7 Claims
 
1. A paramyxovirus virus like particle (VLP) comprising a contiguous recombinant polypeptide comprising i) from 10-120 amino acids of a C-terminal domain of a paramyxovirus nucleocapsid (N) protein, and ii) a polypeptide sequence of a single chain antibody or an antigen binding fragment thereof.