	US 12,264,202 B2
	Methods of reducing or hindering development of ischemia-reperfusion injury due to kidney transplantation with an antibody that inhibits granulocyte-colony stimulating factor (G-CSF) signaling
Ingela Vikstrom, Melbourne (AU); Adriana Baz Morelli, Melbourne (AU); and Martin Pearse, Melbourne (AU)
Assigned to CSL LIMITED, Melbourne (AU)
Filed by CSL Limited, Melbourne (AU)
Filed on Jan. 10, 2023, as Appl. No. 18/152,439.
Application 18/152,439 is a continuation of application No. 16/768,159, abandoned, previously published as PCT/AU2018/051272, filed on Nov. 29, 2018.
Claims priority of application No. 2017904822 (AU), filed on Nov. 29, 2017.
Prior Publication US 2023/0279129 A1, Sep. 7, 2023
Int. Cl. A61K 39/395 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/2866 (2013.01) [A61P 9/10 (2018.01); A61P 13/12 (2018.01); A61K 2039/505 (2013.01); A61K 2039/545 (2013.01); C07K 2317/21 (2013.01); C07K 2317/34 (2013.01); C07K 2317/76 (2013.01)]

11 Claims

1. A method for reducing or hindering development of ischemia-reperfusion injury in a subject, the method comprising administering a compound that inhibits granulocyte colony stimulating factor (G-CSF) signaling, wherein the ischemia-reperfusion injury is due to or associated with tissue or organ transplantation, wherein the tissue or organ transplantation is a kidney transplantation and wherein the compound that inhibits G-CSF signaling is an antibody that specifically binds to G-CSF receptor (G-CSFR) and neutralizes G-CSF signaling,

wherein the compound that inhibits G-CSF signaling is administered in an amount sufficient to have one or more of the following effects 24 hours after reperfusion:

(i) reduce or prevent an increase in serum or plasma creatinine levels;

(ii) reduce or prevent an increase in serum or plasma urea levels;

(iii) reduce or prevent neutrophil infiltration;

(iv) reduce or prevent macrophage infiltration;

(v) reduce or prevent complement C5 activation; and

(vi) reduce or prevent C5b-9 deposition.