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1. A method of treating a subject colonized with Staphylococcus aureus (S. aureus), the method comprising administering an antibody or antigen-binding fragment thereof that binds to S. aureus alpha toxin (AT) to the subject, wherein polymerase chain reaction (PCR) has been used to detect the level of S. aureus in a sample that was obtained from the subject prior to the administering, wherein the sample has a level of S. aureus that does not exceed a level of S. aureus that correlates to a polymerase chain reaction (PCR) cycle threshold (Ct) value of 29 or above, wherein the PCR Ct value of 29 corresponds to a sample concentration of S. aureus that does not exceed 1700 colony forming units (CFU)/mL of S. aureus, and wherein the antibody or antigen-binding fragment thereof that binds to S. aureus AT comprises a variable heavy chain (VH) complementarity determining region (CDR) 1 comprising the amino acid sequence of SEQ ID NO: 1, a VH CDR2 comprising the amino acid sequence of SEQ ID NO:2, a VH CDR3 comprising the amino acid sequence of SEQ ID NO:3, a variable light chain (VL) CDR1 comprising the amino acid sequence of SEQ ID NO:4, a VL CDR2 comprising the amino acid sequence of SEQ ID NO:5, and a VL CDR3 comprising the amino acid sequence of SEQ ID NO:6.
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