US 12,264,192 B2
Modified collagen, methods of manufacture thereof
Andrew Mearns Spragg, Stirling (GB)
Assigned to JELLAGEN PTY LTD, Stirling (GB)
Filed by Jellagen Pty Ltd, Stirling (GB)
Filed on Sep. 27, 2022, as Appl. No. 17/954,001.
Application 17/954,001 is a division of application No. 15/565,817, granted, now 11,485,772, previously published as PCT/GB2016/051025, filed on Apr. 12, 2016.
Claims priority of application No. 1506236 (GB), filed on Apr. 13, 2015.
Prior Publication US 2023/0065054 A1, Mar. 2, 2023
Int. Cl. C07K 14/78 (2006.01); A61K 35/614 (2015.01); A61K 38/01 (2006.01); A61L 15/32 (2006.01); A61L 15/42 (2006.01); A61L 15/44 (2006.01); A61L 15/46 (2006.01); A61L 26/00 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/78 (2013.01) [A61K 35/614 (2013.01); A61K 38/014 (2013.01); A61L 15/325 (2013.01); A61L 15/425 (2013.01); A61L 15/44 (2013.01); A61L 15/46 (2013.01); A61L 26/0033 (2013.01); A61L 26/0066 (2013.01); A61L 26/008 (2013.01); A61L 26/0085 (2013.01); A61K 38/00 (2013.01); A61L 2300/404 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method of producing a modified collagen, comprising at least the steps of:
providing a collagen comprising a S—S bond;
introducing a —SH group in said collagen comprising a S—S bond by reduction of the S—S bond to provide a collagen thiol comprising a —SH group;
nitrosating the —SH group of the collagen thiol to provide a modified collagen, said modified collagen comprising S-nitroso groups.