US 12,264,188 B2
Relaxin-2 fusion proteins
John Diener, Watertown, MA (US); Ryan Knihtila, Watertown, MA (US); and Franz Gruswitz, Watertown, MA (US)
Assigned to TECTONIC OPERATING COMPANY, INC., Watertown, MA (US)
Filed by TECTONIC OPERATING COMPANY, INC., Watertown, MA (US)
Filed on Aug. 9, 2024, as Appl. No. 18/799,714.
Application 18/799,714 is a continuation of application No. PCT/US2024/030016, filed on May 17, 2024.
Claims priority of provisional application 63/617,398, filed on Jan. 3, 2024.
Claims priority of provisional application 63/611,732, filed on Dec. 18, 2023.
Claims priority of provisional application 63/586,868, filed on Sep. 29, 2023.
Claims priority of provisional application 63/585,849, filed on Sep. 27, 2023.
Claims priority of provisional application 63/503,101, filed on May 18, 2023.
Prior Publication US 2024/0409601 A1, Dec. 12, 2024
Int. Cl. C07K 14/64 (2006.01); A61P 43/00 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/64 (2013.01) [A61P 43/00 (2018.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01)] 21 Claims
 
1. A fusion protein comprising, from N-terminus to C-terminus:
a first peptide comprising the amino acid sequence set forth in SEQ ID NO: 1;
a first linker peptide comprising the amino acid sequence set forth in SEQ ID NO: 21; and
a second peptide comprising the amino acid sequence set forth in SEQ ID NO: 8.