CPC C07K 14/4705 (2013.01) [A61K 38/1709 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07K 14/82 (2013.01); A61K 38/00 (2013.01)] | 10 Claims |
1. A method of manufacturing a polypeptide having a length of 7-14 amino acids, wherein the polypeptide is derived from the HD2 domain of human B-cell CLL/lymphoma 9 (BCL9), the polypeptide is capable of undergoing a reaction to form a hydrocarbon crosslinker, and the polypeptide comprises any sequence selected from:
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and wherein:
Xaa1, Xaa2, Xaa3, and Xaa3 are each an α-methyl, α-alkenyl amino acid;
the method comprising using solid phase synthesis to generate the polypeptide.
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