US 12,264,170 B2
Antimicrobial organosilanes
Gary Allred, Wake Forest, NC (US); Lanny Liebeskind, Atlanta, GA (US); William R. Cast, Fort Wayne, IN (US); and Carl Hilliard, Henderson, NV (US)
Assigned to TOPIKOS SCIENTIFIC, INC., Fort Wayne, IN (US)
Filed by TOPIKOS SCIENTIFIC, INC., Fort Wayne, IN (US)
Filed on Apr. 22, 2024, as Appl. No. 18/642,608.
Application 18/642,608 is a continuation of application No. 18/087,555, filed on Dec. 22, 2022, granted, now 12,006,338.
Application 18/087,555 is a continuation of application No. 17/723,168, filed on Apr. 18, 2022.
Application 17/723,168 is a continuation of application No. PCT/US2020/056392, filed on Oct. 19, 2020.
Claims priority of provisional application 63/014,535, filed on Apr. 23, 2020.
Claims priority of provisional application 62/923,372, filed on Oct. 18, 2019.
Prior Publication US 2024/0309026 A1, Sep. 19, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07F 7/18 (2006.01)
CPC C07F 7/1896 (2013.01) 20 Claims
 
1. A quaternary ammonium compound of Formula:

OG Complex Work Unit Chemistry
or pharmaceutically acceptable salt thereof,
wherein
a is 3 or 4;
R1 is C6-C22alkyl;
R2, R3, and R4 are

OG Complex Work Unit Chemistry
X3 is OH or CH2OR7;
R10, R11, and R12 are independently selected from the group consisting of hydrogen, CH2OR7, C1-C8alkyl, and C1-C8hydroxyalkyl;
R13 is selected from the group consisting of CH2OR7, C1-C8alkyl, and C1-C8hydroxyalkyl;
R7 is independently at each occurrence selected from the group consisting of hydrogen and C1-C8alkyl;
each R16 is C1-C4alkyl;
R17 is hydrogen or C1-C8hydroxyalkyl;
X− is a methane sulfonate anion.