US 12,264,147 B2
Substituted carboxamides as inhibitors of WDR5 protein-protein binding
Rima Al-Awar, Toronto (CA); Carlos Armando Zepeda-Velazquez, Mississauga (CA); Gennady Poda, Toronto (CA); Methvin Isaac, Brampton (CA); David Uehling, Toronto (CA); Brian Wilson, Mississauga (CA); Babu Joseph, Oakville (CA); Yong Liu, Oakville (CA); Pandiaraju Subramanian, Oakville (CA); Ahmed Mamai, Mississauga (CA); Michael Prakesch, Toronto (CA); and Julia Katheleen Stille, Ottawa (CA)
Assigned to Propellon Therapeutics Inc., Toronto (CA)
Filed by Propellon Therapeutics Inc., Toronto (CA)
Filed on May 6, 2022, as Appl. No. 17/738,707.
Application 17/738,707 is a continuation of application No. 17/484,534, filed on Sep. 24, 2021, abandoned.
Application 17/484,534 is a continuation of application No. 16/080,866, granted, now 11,319,299, issued on May 3, 2022, previously published as PCT/CA2017/050269, filed on Mar. 1, 2017.
Claims priority of provisional application 62/301,673, filed on Mar. 1, 2016.
Prior Publication US 2023/0219926 A1, Jul. 13, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07C 233/15 (2006.01); A61K 45/06 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/10 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); A61P 35/02 (2006.01)
CPC C07D 401/12 (2013.01) [A61K 45/06 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); A61P 35/02 (2018.01)] 2 Claims
 
1. A compound selected from the group consisting of:

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or a pharmaceutically acceptable salt thereof.