US 12,263,637 B2
Method for producing 3D-printed active substance-releasing systems with active substance depots
Hermann Seitz, Rostock (DE); Roland Matzmohr, Neuendorf (DE); Niels Grabow, Rostock (DE); Michael Teske, Rostock (DE); Thomas Eickner, Rostock (DE); Robert Mau, Rostock (DE); Alexander Riess, Rostock (DE); and Klaus-Peter Schmitz, Rostock (DE)
Assigned to Universitaet Rostock, Rostock (DE)
Filed by UNIVERSITÄT ROSTOCK, Rostock (DE)
Filed on Sep. 29, 2020, as Appl. No. 17/037,099.
Application 17/037,099 is a continuation of application No. PCT/EP2019/057734, filed on Mar. 27, 2019.
Claims priority of application No. 10 2018 107 585.5 (DE), filed on Mar. 29, 2018.
Prior Publication US 2021/0078248 A1, Mar. 18, 2021
Int. Cl. B29C 64/209 (2017.01); A61K 9/00 (2006.01); B29C 64/112 (2017.01); B29C 64/124 (2017.01); B29K 105/00 (2006.01); B33Y 10/00 (2015.01); B33Y 30/00 (2015.01); B33Y 70/00 (2020.01); B33Y 80/00 (2015.01); C09D 11/101 (2014.01); C09D 11/38 (2014.01)
CPC B29C 64/209 (2017.08) [A61K 9/0024 (2013.01); B29C 64/112 (2017.08); B29C 64/124 (2017.08); B33Y 10/00 (2014.12); B33Y 30/00 (2014.12); B33Y 70/00 (2014.12); C09D 11/101 (2013.01); C09D 11/38 (2013.01); B29K 2105/0002 (2013.01); B33Y 80/00 (2014.12)] 13 Claims
OG exemplary drawing
 
1. A hybrid additive method for producing a 3D-printed active substance-releasing system, the method comprising:
sequentially building layers of the 3D-printed active substance-releasing system utilizing:
an inkjet printhead for performing an inkjet printing process, and
a first radiation source with a trough for receiving a base material to be processed and a construction platform in the trough for carrying out a stereolithography process, wherein the base material is a monomer and/or a polymer
the layers being sequentially built by:
polymerizing selected regions of a first layer of the base material that is on the construction platform using the first radiation source to form a polymerized base material at the selected regions; and
spatially selectively incorporating at least one active substance mixture via the at least one inkjet printhead, before and/or after forming the polymerized base material, into the base material and/or into the polymerized base material and/or into an area within the first layer via the inkjet printing process and polymerizing the at least one active substance mixture using the first radiation source to form at least one layer, so that the at least one layer comprises both the polymerized base material and the at least one active substance mixture that has been polymerized, with the polymerized base material and the at least one active substance mixture that has been polymerized being locally separated from each other,
wherein the at least one active substance mixture comprises a monomer and/or a polymer and at least one active substance, and wherein the base material is devoid of the at least one active substance until the spatially selective incorporation of the at least one active substance mixture via the inkjet printing process, and
wherein the at least one active substance is a pharmaceutical drug, a protein, a toxin or a substance used for analytical tasks.