US 12,263,467 B2
Mixed mode cation exchange chromatography ligands based on 1,3-dioxoisoindolin-2-yl structures
Christopher Belisle, Walnut Creek, CA (US); Jiali Liao, San Ramon, CA (US); and Edwin Lozano, Berkeley, CA (US)
Assigned to BIO-RAD LABORATORIES, INC., Hercules, CA (US)
Filed by BIO-RAD LABORATORIES, INC., Hercules, CA (US)
Filed on Jul. 28, 2023, as Appl. No. 18/360,870.
Application 18/360,870 is a continuation of application No. 17/696,917, filed on Mar. 17, 2022, granted, now 11,731,108.
Claims priority of provisional application 63/162,092, filed on Mar. 17, 2021.
Prior Publication US 2024/0001338 A1, Jan. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. B01J 20/28 (2006.01); B01D 15/38 (2006.01); B01J 20/285 (2006.01); B01J 20/289 (2006.01); B01J 20/30 (2006.01); C07K 1/16 (2006.01)
CPC B01J 20/285 (2013.01) [B01D 15/3809 (2013.01); B01D 15/3847 (2013.01); B01J 20/28085 (2013.01); B01J 20/289 (2013.01); B01J 20/3042 (2013.01); C07K 1/165 (2013.01); B01J 2220/52 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A mixed-mode chromatography medium comprising one or more ligand coupled to a solid support, said ligand comprising a 1,3-dioxoisoindolin-2-yl group and said ligand being coupled to said solid support at a 1,3-dioxoisoindolin-2-yl group through a chain of one to five atoms.