US 12,263,449 B2
Tangential flow filtration manifold
John F. Connors, Jr., Shrewsbury, MA (US)
Filed by John F. Connors, Jr., Shrewsbury, MA (US)
Filed on Jun. 14, 2022, as Appl. No. 17/839,532.
Claims priority of provisional application 63/210,234, filed on Jun. 14, 2021.
Prior Publication US 2022/0395782 A1, Dec. 15, 2022
Int. Cl. B01D 63/08 (2006.01)
CPC B01D 63/0822 (2022.08) [B01D 63/081 (2013.01); B01D 2221/10 (2013.01); B01D 2313/105 (2013.01); B01D 2313/125 (2013.01); B01D 2313/2031 (2022.08); B01D 2313/54 (2013.01); B01D 2315/10 (2013.01); B01D 2319/04 (2013.01)] 12 Claims
OG exemplary drawing
 
1. In a tangential flow filtration (TFF) apparatus for directing a feed across a filter membrane to a permeate passing through the filter and an unfiltered retentate, a manifold device for directing the feed, retentate and permeate to a filter assembly defined by stack of filter cassettes, comprising:
a manifold surface having a first side and a second side, the first side opposed from the second side;
a feed channel fluidically coupling a feed port to a feed outlet for fluid communication with the filter assembly, the feed outlet on the manifold surface adjacent to the first side;
a retentate channel fluidically coupling a retentate inlet to a retentate port, the retentate inlet configured for fluidic communication for receiving retentate from the filter assembly, the retentate inlet on the manifold surface adjacent to the second side;
at least two permeate inlets on the manifold surface and configured to receive permeate from the filter assembly in a respective plurality of permeate channels through the manifold, including at least one of the permeate inlets adjacent to the first side and at least one permeate inlet adjacent to the second side,
each of the permeate inlets aligned with corresponding orifices on the filter assembly, the permeate channels fluidically coupled to a single, aggregate permeate port for output of the permeate via a common outflow;
a union fluidically coupling each of the plurality of permeate channels from each of the permeate inlets to the common outflow for output of the permeate from the filter assembly via the single, aggregate permeate port, each permeate channel receiving the permeate from the filter assembly via a respective permeate inlet, each of the permeate inlets adjacent to the first side or the second side of the manifold;
the permeate channels further comprising a junction channel, the junction channel extending under the manifold surface continuously from the at least one permeate inlet adjacent the second side to the at least one permeate inlet adjacent the first side, the junction channel forming fluidic communication with the plurality of permeate inlets and the common outflow.