US 12,263,313 B2
Urinary system catheter using ethanol extract of propolis as coating and preparation method thereof
Luo Yang, Chengdu (CN)
Assigned to Sichuan University, Chengdu (CN)
Filed by Sichuan University, Chengdu (CN)
Filed on Jun. 5, 2024, as Appl. No. 18/733,907.
Claims priority of application No. 202311081697.5 (CN), filed on Aug. 25, 2023.
Prior Publication US 2025/0065076 A1, Feb. 27, 2025
Int. Cl. A61K 35/644 (2015.01); A61L 29/08 (2006.01); A61L 29/16 (2006.01); A61M 25/00 (2006.01); B01D 11/02 (2006.01); C08L 93/00 (2006.01); C09D 193/04 (2006.01); A61P 31/04 (2006.01); C08L 93/04 (2006.01)
CPC A61M 25/0017 (2013.01) [A61K 35/644 (2013.01); A61L 29/08 (2013.01); A61L 29/16 (2013.01); B01D 11/02 (2013.01); B01D 11/0265 (2013.01); B01D 11/0288 (2013.01); C08L 93/00 (2013.01); C09D 193/04 (2013.01); A61L 2300/30 (2013.01); A61L 2300/404 (2013.01); A61P 31/04 (2018.01); C08L 93/04 (2013.01); C08L 2666/26 (2013.01)] 10 Claims
 
1. An antimicrobial and anti-infective urinary system catheter, comprising:
a surface of a urinary system catheter; and
a coating of a propolis alcohol extract directly covered on the surface of the urinary system catheter, to enhance hydrophilicity of the surface of the urinary system catheter, prevent stones and scabs forming on the surface of the urinary system catheter, and make the urinary system catheter antimicrobial and anti-infective;
wherein the propolis alcohol extract is an ethanol extract of propolis, and a preparation method of the ethanol extract of propolis comprises the following steps: adding ethanol into propolis to perform ultrasonic extraction to obtain an extract, and filtering the extract to obtain supernatant, thereby obtaining the ethanol extract of propolis;
wherein the ethanol is an ethanol solution with a volume percentage of 75%;
wherein a mass of the ethanol is 25 times of a mass of the propolis;
wherein a temperature of the ultrasonic extraction is 60 degrees Celsius (° C.), a frequency of the ultrasonic extraction is 37 kilohertz (kHz), a power of the ultrasonic extraction is 100 watts (W), and a time for the ultrasonic extraction is 60 minutes (min); and
wherein a method for covering the surface of the urinary system catheter with the coating of the propolis alcohol extract comprises the following steps: immersing the urinary system catheter into a solution of the ethanol extract of propolis, and then taking out and drying to obtain the antimicrobial and anti-infective urinary system catheter;
wherein a solvent of the solution of the ethanol extract of propolis is the ethanol with the volume percentage of 75%, and a concentration of the solution of the ethanol extract of propolis is in a range of 32 milligrams per milliliter (mg/mL) to 128 mg/mL;
wherein the coating of the propolis alcohol extract comprises: total flavonoids and total phenolic acid, and an average surface propolis content of the coating of the propolis alcohol extract is greater than or equal to 0.721 according to the following formula for calculating the average surface propolis content:

OG Complex Work Unit Math
where total flavonoids content in solution represents content of the total flavonoids in a dissolved solution of the coating of the propolis alcohol extract, total phenolic acid content in solution represents content of the total phenolic acid in the dissolved solution of the coating of the propolis alcohol extract, surface area of segment represents an area of the surface of the urinary system catheter coated with the coating of the propolis alcohol extract; and
wherein a contact angle between the coating of the propolis alcohol extract covered on the surface of the urinary system catheter and water is less than 90°.