US 12,263,286 B2
Medicament preparation devices, methods, and systems
Goetz Friederichs, Beverly, MA (US); and Kevin Hughes, North Andover, MA (US)
Assigned to NxStage Medical, Inc., Lawrence, MA (US)
Appl. No. 17/612,747
Filed by NxStage Medical, Inc., Lawrence, MA (US)
PCT Filed May 21, 2020, PCT No. PCT/US2020/033967
§ 371(c)(1), (2) Date Nov. 19, 2021,
PCT Pub. No. WO2020/237033, PCT Pub. Date Nov. 26, 2020.
Claims priority of provisional application 62/851,893, filed on May 23, 2019.
Prior Publication US 2022/0241478 A1, Aug. 4, 2022
Int. Cl. B01F 25/00 (2022.01); A61M 1/16 (2006.01); B01F 23/45 (2022.01); B01F 25/50 (2022.01); B01F 35/00 (2022.01); B01F 35/71 (2022.01); B01F 35/83 (2022.01); B01F 35/21 (2022.01); B01F 101/22 (2022.01)
CPC A61M 1/1656 (2013.01) [B01F 23/45 (2022.01); B01F 25/50 (2022.01); B01F 35/181 (2022.01); B01F 35/717611 (2022.01); B01F 35/71805 (2022.01); B01F 35/831 (2022.01); B01F 35/2133 (2022.01); B01F 2101/22 (2022.01)] 16 Claims
OG exemplary drawing
 
1. A system for mixing a batch of medicament, comprising:
a pump actuator and control valve actuators controlled by a controller;
a fluid circuit fluidly connected to the pump actuator and the valve actuators;
the fluid circuit including a concentrate container filled with a concentrate or a concentrate connector for connection to the concentrate container;
the fluid circuit being connected to a mixing container by an inlet line and an outlet line of the mixing container at ends of a pumping tube segment that engages the pump actuator to form a peristaltic pump;
a water pump connected to the system and controlled by the controller, the water pump being configured to pump purified water from a purified water source;
the controller being configured to control the valve actuators to open fluid channels from the concentrate container or the concentrate connector and to open channels from the purified water source to connect a junction of the fluid circuit to the concentrate container and the purified water source;
the controller being further configured to control the pump actuator and the water pump to flow water and concentrate into said junction, the junction being connected to the inlet line of the mixing container, such that water and concentrate flow concurrently into the mixing container;
the controller being further configured to control the peristaltic pump and the water pump to flow concentrate in proportion such that a mixture of the concentrate and the purified water in the mixing container requires additional dilution to form a ready-to-use medicament;
the fluid circuit having a drain line connectable to a conductivity sensor and the controller being configured to collect a sample of contents of the mixing container through the drain line and to measure a conductivity of the sample with the conductivity sensor; and
the controller being further configured to calculate an additional quantity of water to add to the mixing container responsively to the conductivity measured.