	US 12,263,276 B2
	Amnion tissue grafts and methods of preparing and using same
Curt Deister, Alachua, FL (US)
Assigned to Axogen Corporation, Alachua, FL (US)
Filed by Axogen Corporation, Alachua, FL (US)
Filed on Jan. 13, 2023, as Appl. No. 18/154,461.
Application 18/154,461 is a division of application No. 16/346,607, granted, now 11,577,001, previously published as PCT/US2017/059700, filed on Nov. 2, 2017.
Claims priority of provisional application 62/416,528, filed on Nov. 2, 2016.
Prior Publication US 2023/0191001 A1, Jun. 22, 2023
Int. Cl. A61L 27/38 (2006.01); A01N 1/00 (2006.01); A61K 35/12 (2015.01); A61L 27/36 (2006.01)

CPC A61L 27/3804 (2013.01) [A01N 1/00 (2013.01); A61K 35/12 (2013.01); A61L 27/3604 (2013.01); A61L 27/3687 (2013.01); A61L 27/3691 (2013.01); A61L 27/3895 (2013.01)]

28 Claims

1. An amnion tissue graft comprising:

a single membrane of umbilical cord amnion, wherein a smooth surface is created by Wharton's jelly, wherein the amnion tissue graft comprises less than about 20% water by weight and a thickness of about 150 μm to about 250 μm, and

wherein (1) the amnion tissue graft is formed by removing blood vessels and some, but not all, of the Wharton's jelly from the umbilical cord amnion or (2) the thickness of the amnion tissue graft, including the Wharton's jelly, varies by less than 20% across a surface of the amnion tissue graft when dried.