US 12,263,275 B2
Fistula filler and deployment system
Dominique Davidow, Minnetonka, MN (US); Aleksandr Katane, Victoria, MN (US); and Ben Steiner, Bloomington, MN (US)
Assigned to Miromatrix Medical Inc., Eden Prairie, MN (US)
Appl. No. 17/251,573
Filed by MIROMATRIX MEDICAL INC., Eden Prarie, MN (US)
PCT Filed Jun. 13, 2019, PCT No. PCT/US2019/036942
§ 371(c)(1), (2) Date Dec. 11, 2020,
PCT Pub. No. WO2019/241499, PCT Pub. Date Dec. 19, 2019.
Claims priority of provisional application 62/684,426, filed on Jun. 13, 2018.
Prior Publication US 2021/0236695 A1, Aug. 5, 2021
Int. Cl. A61L 27/04 (2006.01); A61L 27/14 (2006.01); A61L 27/36 (2006.01)
CPC A61L 27/3633 (2013.01) [A61L 27/04 (2013.01); A61L 27/14 (2013.01); A61L 27/3641 (2013.01); A61L 27/3683 (2013.01); A61L 2430/40 (2013.01)] 24 Claims
 
1. A system, comprising:
an isolated molded, at least partially irradiated portion of an at least partially decellularized extracellular matrix from a mammalian organ or tissue, the at least partially decellularized extracellular matrix from the mammalian organ or tissue having a scaffold comprising a plurality of collagen fibers surrounding a plurality of empty cellular compartments and having an architecture of the extracellular matrix or portion thereof prior to decellularization when placed inside of a mold or constraining device and exposed to radiation,
wherein the isolated molded, at least partially irradiated portion of the at least partially decellularized extracellular matrix has reduced malleability relative to a comparable, non-irradiated portion and is in the form of a cylinder, cube, rectangular prism, or irregular strip, depending on a configuration of the mold or constraining device, and
wherein the system does not include a surgical mesh.