	US 12,263,273 B2
	Porous biomaterials for tissue regeneration
Radovan Vukicevic, Frankfurt (DE); and Alexander Linko, Frankfurt am Main (DE)
Assigned to MERZ PHARMA GMBH &CO. KGAA, Frankfurt am Main (DE)
Appl. No. 16/975,418
Filed by MERZ PHARMA GMBH & CO. KGAA, Frankfurt am Main (DE)
PCT Filed Mar. 8, 2019, PCT No. PCT/EP2019/055801 § 371(c)(1), (2) Date Aug. 25, 2020, PCT Pub. No. WO2019/175036, PCT Pub. Date Sep. 19, 2019.
Claims priority of application No. 18161300 (EP), filed on Mar. 12, 2018.
Prior Publication US 2021/0008249 A1, Jan. 14, 2021
Int. Cl. A61L 27/26 (2006.01); A61K 8/02 (2006.01); A61K 8/64 (2006.01); A61K 8/73 (2006.01); A61L 27/20 (2006.01); A61L 27/22 (2006.01); A61L 27/56 (2006.01); A61Q 19/08 (2006.01); C08B 37/08 (2006.01); C08L 1/02 (2006.01); C08L 5/08 (2006.01); C08L 5/10 (2006.01)

CPC A61L 27/26 (2013.01) [A61K 8/0279 (2013.01); A61K 8/64 (2013.01); A61K 8/735 (2013.01); A61K 8/736 (2013.01); A61L 27/20 (2013.01); A61L 27/225 (2013.01); A61L 27/227 (2013.01); A61L 27/56 (2013.01); A61Q 19/08 (2013.01); C08B 37/0072 (2013.01); C08L 1/02 (2013.01); C08L 5/08 (2013.01); C08L 5/10 (2013.01); A61K 2800/84 (2013.01); A61K 2800/91 (2013.01); A61L 2400/06 (2013.01); A61L 2430/34 (2013.01)]

19 Claims

1. A porous material having a scaffold comprising:

one or more fibroin moieties A; and

one or more hyaluronic acid (HA) moieties B,

wherein A and B are directly covalently conjugated to one another without an interconnecting linker structure via a reaction of one or more aldehyde groups of B with an epsilon amino group of a lysyl residue of A,

wherein said porous material has pores with an overall inner pore volume, wherein the pores are filled with air in a dry state and with a liquid or a viscous fluid in a wet state, and an overall volume of solid content of said porous material, and

wherein, in an uncompressed form, the sum of the overall inner pore volume of the porous material is larger than the overall volume of the solid content of the porous material.