US 12,263,272 B2
Bone graft composition and manufacturing method thereof
JungBok Park, Busan (KR)
Assigned to MedPark Co., Ltd, Busan (KR)
Filed by MedPark Co., Ltd, Busan (KR)
Filed on Jul. 13, 2020, as Appl. No. 16/927,845.
Claims priority of application No. 10-2020-0039212 (KR), filed on Mar. 31, 2020.
Prior Publication US 2021/0299327 A1, Sep. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/26 (2006.01); A61L 27/56 (2006.01)
CPC A61L 27/26 (2013.01) [A61L 27/56 (2013.01); A61L 2430/02 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A bone graft composition consisting of a bone graft material and hydroxypropyl methylcellulose (HPMC),
wherein the HPMC maintains the shape of the bone graft composition after implantation in a bone defect portion so as to have a shape retainability of 50 or more,
wherein the shape retainability is defined as a value obtained by dividing a maximum breaking force (Nmax) by a short-axis change rate, in which the maximum breaking force (Nmax) is a force at which a change in shape of a sphere-shaped material is initiated by applying a force (N) to one side of the sphere-shaped material, and the short-axis change rate is a ratio (D-S)/(D) of a reduction in short-axis length (S) of the sphere-shaped material, measured after the change in the shape occurred, to a diameter (D) of the sphere-shaped material,
wherein the bone graft composition consists of 1 to 3 parts by weight of the HPMC with respect to 1 part by weight of the bone graft material for enhancing the shape retention ability, and
wherein the bone graft material consists of an autogenous bone graft material, an allogeneic bone graft material, or a xenogenic bone graft material.