US 12,263,270 B2
Acoustic extracellular matrix hydrogels and their use
Stephen Francis Badylak, West Lafayette, IN (US); and George S. Hussey, Cranberry Township, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Appl. No. 17/434,925
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
PCT Filed Mar. 12, 2020, PCT No. PCT/US2020/022433
§ 371(c)(1), (2) Date Aug. 30, 2021,
PCT Pub. No. WO2020/186082, PCT Pub. Date Sep. 17, 2020.
Claims priority of provisional application 62/950,565, filed on Dec. 19, 2019.
Claims priority of provisional application 62/817,787, filed on Mar. 13, 2019.
Prior Publication US 2022/0143265 A1, May 12, 2022
Int. Cl. A61K 31/00 (2006.01); A61L 26/00 (2006.01); A61L 27/36 (2006.01); A61L 27/52 (2006.01)
CPC A61L 26/0057 (2013.01) [A61L 26/008 (2013.01); A61L 27/3633 (2013.01); A61L 27/52 (2013.01); A61L 2400/04 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A method of producing an extracellular matrix (ECM) hydrogel, comprising:
solubilizing mammalian ECM in a liquid using ultrasound frequency to produce an acoustic ECM hydrogel in a liquid phase, wherein the mammalian ECM is present at a concentration of about 25 mg/ml to about 600 mg/ml.