US 12,263,249 B2
Formation of particles including agents
Chase Spenser Coffman, Newton, MA (US); Lyndon Fitzgerald Charles, Jr., Medford, MA (US); Paul Brown, Boston, MA (US); Daniel Benjamin Dadon, East Boston, MA (US); Lisa Liu, Somerville, MA (US); Cory Robinson, Cambridge, MA (US); and Dale Arlington Thomas, III, Hampden, ME (US)
Assigned to Elektrofi, Inc., Boston, MA (US)
Filed by Elektrofi, Inc., Boston, MA (US)
Filed on Jun. 30, 2021, as Appl. No. 17/364,770.
Application 17/364,770 is a division of application No. 16/633,097, granted, now 11,077,059, previously published as PCT/US2018/043774, filed on Jul. 25, 2018.
Claims priority of provisional application 62/676,195, filed on May 24, 2018.
Claims priority of provisional application 62/536,746, filed on Jul. 25, 2017.
Prior Publication US 2021/0322317 A1, Oct. 21, 2021
Int. Cl. A61K 9/14 (2006.01); B01J 2/06 (2006.01)
CPC A61K 9/145 (2013.01) [A61K 9/146 (2013.01); B01J 2/06 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A composition comprising particles, wherein a plurality of particles are round particles having a sphericity greater than 0.9, wherein the plurality of particles comprise an excipient and a therapeutic agent, wherein a mass loading of the therapeutic agent in the plurality of particles is between 50% and 100%, wherein the therapeutic agent is a protein, peptide, or nucleic acid, and wherein the excipient is a salt, an amino acid, a surfactant, or a carbohydrate.