US 12,263,244 B2
Intravesical device for controlled drug delivery
Heejin Lee, Bedford, MA (US); Michael J. Cima, Winchester, MA (US); Karen Daniel, Newton, MA (US); and Cheryl Larrivee-Elkins, Framingham, MA (US)
Assigned to TARIS Biomedical LLC, Lexington, MA (US)
Filed by TARIS Biomedical LLC, Lexington, MA (US)
Filed on Sep. 9, 2021, as Appl. No. 17/470,541.
Application 14/677,182 is a division of application No. 12/851,494, filed on Aug. 5, 2010, granted, now 9,017,312, issued on Apr. 28, 2015.
Application 17/470,541 is a continuation of application No. 15/815,843, filed on Nov. 17, 2017, granted, now 11,135,161.
Application 15/815,843 is a continuation of application No. 14/677,182, filed on Apr. 2, 2015, abandoned.
Application 12/851,494 is a continuation in part of application No. 12/825,215, filed on Jun. 28, 2010, granted, now 10,543,166, issued on Jan. 28, 2020.
Claims priority of provisional application 61/241,277, filed on Sep. 10, 2009.
Prior Publication US 2021/0401741 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01); A61K 31/167 (2006.01); A61M 31/00 (2006.01)
CPC A61K 9/0092 (2013.01) [A61K 9/0004 (2013.01); A61K 9/0034 (2013.01); A61K 31/167 (2013.01); A61M 31/002 (2013.01); A61M 2210/1085 (2013.01)] 24 Claims
OG exemplary drawing
 
1. An intravesical device for drug delivery to the urinary bladder of a patient, comprising:
a tubular device body which comprises a drug reservoir lumen and a retention frame lumen;
a drug formulation comprising a plurality of aligned solid drug units, which comprise a drug, disposed in the drug reservoir lumen; and
a nitinol retention frame disposed in the retention frame lumen,
wherein the device has no drug release aperture and releases the drug by trans-wall diffusion; and
wherein the solid drug units are tablets each of which has a cylindrical side face and a length:width aspect ratio greater than 1:1.