	US 12,263,243 B2
	Templated open flocs of anisotropic particles for enhanced pulmonary delivery
Keith P. Johnston, Austin, TX (US); Joshua Engstrom, Spotswood, NJ (US); Jasmine Tam, Austin, TX (US); Robert O. Williams, III, Austin, TX (US); and Alan B. Watts, Austin, TX (US)
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed by Keith P. Johnston, Austin, TX (US); Joshua Engstrom, Spotswood, NJ (US); Jasmine Tam, Austin, TX (US); Robert O. Williams, III, Austin, TX (US); and Alan B. Watts, Austin, TX (US)
Filed on Feb. 13, 2009, as Appl. No. 12/371,573.
Claims priority of provisional application 61/028,218, filed on Feb. 13, 2008.
Prior Publication US 2009/0208582 A1, Aug. 20, 2009
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/00 (2006.01)

CPC A61K 9/008 (2013.01) [A61K 9/0075 (2013.01)]

7 Claims

1. Flocculated pharmaceutically active starting drug particles (“starting floc drug particles”), of one or more drugs, the starting floc drug particles having aerodynamic diameters that have not been pre-formed, the starting floc drug particles being positioned in a dry powder inhaler (dpi) having one or more particle exit orifices, the starting floc drug particles being anisotropic and asymmetric such that when the dpi is actuated, the starting floc drug particles pass through the one or more exit orifices of the dpi and into patient air ways, the starting floc drug particles will break up and produce smaller floc drug particles having aerodynamic diameters that are of a size appropriate for deep lung delivery ranging between 1 and 5 microns.