US 12,263,239 B2
External composition containing ascorbic acid and/or salt thereof
Yu Kitaoka, Osaka (JP); and Masatoshi Haga, Osaka (JP)
Assigned to ROHTO PHARMACEUTICAL CO., LTD., Osaka (JP)
Appl. No. 16/958,389
Filed by ROHTO PHARMACEUTICAL CO., LTD., Osaka (JP)
PCT Filed Dec. 27, 2018, PCT No. PCT/JP2018/048188
§ 371(c)(1), (2) Date Jun. 26, 2020,
PCT Pub. No. WO2019/131892, PCT Pub. Date Jul. 4, 2019.
Claims priority of application No. 2017-252208 (JP), filed on Dec. 27, 2017.
Prior Publication US 2021/0052481 A1, Feb. 25, 2021
Int. Cl. A61K 8/67 (2006.01); A61K 8/34 (2006.01); A61K 8/41 (2006.01); A61Q 19/02 (2006.01); A61Q 19/08 (2006.01)
CPC A61K 8/676 (2013.01) [A61K 8/345 (2013.01); A61K 8/416 (2013.01); A61Q 19/02 (2013.01); A61Q 19/08 (2013.01)] 10 Claims
 
1. An external composition, comprising:
(A) at least one selected from the group consisting of an ascorbic acid and an ascorbic salt in an amount of 1 mass % to 40 mass %;
(B) 25 mass % or more of a diol having 3 carbon atoms;
(C) at least one low-molecular-weight betaine in an amount of 0.01 mass % to 10 mass %; and
(D) 5 to 40 mass % of water,
and a content of ethoxydiglycol is 0 to 10 mass %.