	US 12,263,223 B2
	Method of treating diseases of the kidney and urinary tract by administering a peptide-linked therapeutic agent
Shek Hang Benedict Law, New York, NY (US); Vanessa Bellat, New York, NY (US); and Benjamin Byung-min Choi, Englewood Cliffs, NJ (US)
Assigned to Cornell University, Ithaca, NY (US); and Tu Therapeutics Inc., New York, NY (US)
Filed by Cornell University, Ithaca, NY (US); and Tu Therapeutics Inc., New York, NY (US)
Filed on Jan. 11, 2023, as Appl. No. 18/095,753.
Application 18/095,753 is a continuation of application No. 17/556,714, filed on Dec. 20, 2021, granted, now 11,571,481.
Claims priority of provisional application 63/254,754, filed on Oct. 12, 2021.
Claims priority of provisional application 63/128,509, filed on Dec. 21, 2020.
Prior Publication US 2023/0190948 A1, Jun. 22, 2023
Int. Cl. A61K 47/65 (2017.01); A61K 45/06 (2006.01); A61K 47/18 (2017.01); A61P 13/10 (2006.01); A61P 35/00 (2006.01)

CPC A61K 47/65 (2017.08) [A61K 45/06 (2013.01); A61K 47/183 (2013.01); A61P 13/10 (2018.01); A61P 35/00 (2018.01)]

19 Claims

1. A method of treating a condition selected from kidney, urinary tract or bladder cancer cancer, a urinary tract infection, overactive bladder, urinary incontinence, interstitial cystitis and kidney stones comprising administering to a patient in need thereof a compound represented by formula (I):

or a pharmaceutically acceptable salt thereof, wherein:

the active moiety is a therapeutic agent; and

the peptide is negatively charged at physiological pH and comprises a sequence:

wherein:

one of X, Y and Z is a β-amino acid residue;

two of X, Y and Z are independently α-amino acid residues that each have at least one side chain that comprises a carboxylic acid group;

each α-amino acid residue is independently of D or L stereochemistry; and

m is from 2 to 10.