	US 12,263,215 B2
	Cytotoxic immunostimulating particles and uses thereof
Steve Pascolo, Zürich (CH)
Assigned to BIONTECH SE, Mainz (DE)
Filed by BIONTECH SE, Mainz (DE)
Filed on Mar. 23, 2021, as Appl. No. 17/209,926.
Application 17/209,926 is a continuation of application No. 15/763,541, granted, now 10,980,875, previously published as PCT/EP2016/075146, filed on Oct. 20, 2016.
Claims priority of application No. PCT/EP2015/074386 (WO), filed on Oct. 21, 2015.
Prior Publication US 2021/0205447 A1, Jul. 8, 2021
Int. Cl. A61K 39/39 (2006.01); A61K 35/13 (2015.01); A61K 39/00 (2006.01)

CPC A61K 39/39 (2013.01) [A61K 35/13 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/572 (2013.01)]

19 Claims

1. A particle comprising single stranded RNA (ssRNA), in which the ssRNA is associated with a cationic polymer or lipid or with both a cationic polymer and lipid,

wherein the ssRNA comprises fluorouridine and one or more other types of cytotoxic nucleotides or cytotoxic nucleotide analogs.