US 12,263,214 B2
Vaccine for use in the prophylaxis and/or treatment of a disease
Peter Holst, Soeborg (DK); Christian Thirion, Munich (DE); and Lasse Neukirch, Flensburg (DE)
Assigned to INPROTHER APS, Copenhagen (DK)
Filed by INPROTHER APS, Copenhagen (DK)
Filed on Jan. 16, 2024, as Appl. No. 18/414,053.
Application 18/414,053 is a continuation of application No. 17/732,127, filed on Apr. 28, 2022, granted, now 11,883,487.
Application 17/732,127 is a continuation of application No. 16/643,095, granted, now 11,351,247, issued on Jun. 7, 2022, previously published as PCT/EP2018/073404, filed on Aug. 30, 2018.
Claims priority of application No. PA 2017 70659 (DK), filed on Sep. 1, 2017.
Prior Publication US 2024/0148860 A1, May 9, 2024
Int. Cl. A61K 39/21 (2006.01); A61K 39/12 (2006.01); A61K 39/235 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/235 (2013.01) [A61K 39/21 (2013.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 2039/525 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/545 (2013.01); A61K 2039/585 (2013.01); C12N 2710/10043 (2013.01); C12N 2740/10022 (2013.01); C12N 2740/10023 (2013.01); C12N 2740/10034 (2013.01); C12N 2740/10071 (2013.01)] 13 Claims
 
1. A virus-like particle (VLP), wherein the VLP is encoded by a nucleic acid molecule encoding a Gag protein and an ERV envelope (Env) protein or an immunogenic part thereof, wherein the native genomic structure connecting Gag and Env has been replaced by an operative linker, wherein the ERV is HERV-K.