US 12,263,193 B2
System and method for removing uremic toxins from a patient's body
Paul Yager, Seattle, WA (US); Jonathan Himmelfarb, Seattle, WA (US); Mari-Karoliina Henriikka Winkler, Seattle, WA (US); Erin Heiniger, Seattle, WA (US); Sujatha Kumar, Seattle, WA (US); David Stahl, Seattle, WA (US); and Bruce Godfrey, Seattle, WA (US)
Assigned to University of Washington, Seattle, WA (US)
Appl. No. 17/284,759
Filed by University of Washington, Seattle, WA (US)
PCT Filed Oct. 14, 2019, PCT No. PCT/US2019/056119
§ 371(c)(1), (2) Date Apr. 12, 2021,
PCT Pub. No. WO2020/077338, PCT Pub. Date Apr. 16, 2020.
Claims priority of provisional application 62/744,966, filed on Oct. 12, 2018.
Prior Publication US 2022/0000938 A1, Jan. 6, 2022
Int. Cl. A61K 35/74 (2015.01); A61K 9/16 (2006.01)
CPC A61K 35/74 (2013.01) [A61K 9/1652 (2013.01); A61K 9/1658 (2013.01); A61K 9/1682 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A composition for reducing concentration of one or more uremic toxins or uremic toxin precursors in a patient's digestive system, the composition comprising a plurality of hydrogel particles, each particle comprising an agent encapsulated and retained within the particle and capable of reducing a local concentration of one or more uremic toxins or uremic toxin precursors;
wherein the hydrogel particles comprise a shell and a core,
wherein the core comprises one or more agents disposed within one or more indigestible hydrogel spheres,
wherein the shell allows diffusion of uremic toxin into the core, and
wherein the composition further comprises a fluid carrier containing the plurality of hydrogel particles.