	US 12,263,187 B2
	Treatment of bone marrow pathologies with polysulfated polysaccharides
Ravi Krishnan, Royston Park (AU); and Paul Rennie, West Beach (AU)
Assigned to PARADIGM BIOPHARMACEUTICALS LTD, Melbourne (AU)
Filed by PARADIGM BIOPHARMACEUTICALS LTD, Melbourne (AU)
Filed on Mar. 2, 2023, as Appl. No. 18/116,417.
Application 18/116,417 is a continuation of application No. 16/636,545, granted, now 11,617,763, previously published as PCT/AU2018/050816, filed on Aug. 6, 2018.
Claims priority of application No. 2017903094 (AU), filed on Aug. 4, 2017.
Prior Publication US 2023/0241099 A1, Aug. 3, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/737 (2006.01); A61K 9/00 (2006.01); A61P 19/08 (2006.01)

CPC A61K 31/737 (2013.01) [A61K 9/0019 (2013.01); A61P 19/08 (2018.01)]

13 Claims

1. A method for improving knee function and reducing knee pain in a human having osteoarthritis 3-4 on the Kellgren-Lawrence scale in a knee and experiencing pain of at least 8 on the NRS scale, the method including determining that treatment of the knee with a corticosteroid has failed to improve knee function and reduce pain and administering intramuscularly an amount of an acceptable salt of pentosan polysulfate, to the human in need of such treatment, in a manner so as to improve knee function by about 23% to about 89% as determined by Lysholm Knee Score.