US 12,263,186 B2
Methods for treating or preventing obesity and body weight management
Nuo Wang, Newtown, PA (US); Shaohui Lin, Princeton, NJ (US); and Xuening Hu, Plainsboro, NJ (US)
Assigned to Brillian Pharma Inc., Monmouth Junction, NJ (US)
Appl. No. 17/618,030
Filed by Brillian Pharma Inc., Monmouth Junction, NJ (US)
PCT Filed Sep. 23, 2020, PCT No. PCT/US2020/052084
§ 371(c)(1), (2) Date Dec. 10, 2021,
PCT Pub. No. WO2021/067076, PCT Pub. Date Apr. 8, 2021.
Claims priority of provisional application 62/908,929, filed on Oct. 1, 2019.
Prior Publication US 2022/0257637 A1, Aug. 18, 2022
Int. Cl. A61K 31/732 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/734 (2006.01); A61K 45/06 (2006.01); A61K 47/12 (2006.01)
CPC A61K 31/732 (2013.01) [A61K 9/0095 (2013.01); A61K 9/08 (2013.01); A61K 31/734 (2013.01); A61K 45/06 (2013.01); A61K 47/12 (2013.01)] 48 Claims
 
1. A method for or treatment of obesity or overweight, comprising a step-wise administration of a two-portion solution system to a subject suffering from obesity or overweight, wherein the two-portion solution system comprises a first solution and a second solution and the step-wise administration comprises:
(i) administrating a unit dosage of the first solution comprising a cross-linker for crosslinking a hydrogel; and
(ii) administrating a unit dosage of the second solution comprising a cross-linkable hydrogel polymer after the administration of the first solution,
wherein the two-portion solution system forms a cross-linked hydrogel mass that is water-insoluble and has a volume of equal to or greater than 50% (v/v) of the total volume of the two-portion solution system.