	US 12,263,182 B2
	Method of introducing an mRNA molecule into a cell
Anders Høgset, Oslo (NO)
Assigned to PCI BIOTECH AS, Oslo (NO)
Appl. No. 16/963,583
Filed by PCI Biotech AS, Oslo (NO)
PCT Filed Jan. 24, 2019, PCT No. PCT/EP2019/051749 § 371(c)(1), (2) Date Jul. 21, 2020, PCT Pub. No. WO2019/145419, PCT Pub. Date Aug. 1, 2019.
Claims priority of application No. 1801169 (GB), filed on Jan. 24, 2018.
Prior Publication US 2021/0052628 A1, Feb. 25, 2021
Int. Cl. A61K 31/7105 (2006.01); A61K 41/00 (2020.01); C07C 13/00 (2006.01)

CPC A61K 31/7105 (2013.01) [A61K 41/0071 (2013.01); C07C 13/00 (2013.01)]

29 Claims

1. A pharmaceutical composition comprising an mRNA molecule and a photosensitising agent, wherein said mRNA molecule is naked and not bound or conjugated to or carried by any other component to aid its internalization and said photosensitising agent is a sulphonated meso-tetraphenyl chlorin, sulfonated tetraphenylporphine or a di- or tetrasulfonated aluminium phthalocyanine and is provided in the amount of 0.0001 to 0.1 μg and said mRNA is provided in an amount of 1 to 10 μg.