	US 12,263,163 B2
	Crystalline succinate salt of 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as a Syk inhibitor
Peter A. Blomgren, Issaquah, WA (US); Kevin S. Currie, North Bend, WA (US); Jeffrey E. Kropf, Issaquah, WA (US); Seung H. Lee, Sammamish, WA (US); Jennifer R. Lo, Seattle, WA (US); Scott A. Mitchell, Kenmore, WA (US); Aaron C. Schmitt, Hamden, CT (US); Jin-Ming Xiong, Bel Air, MD (US); Jianjun Xu, Bellevue, WA (US); Sundaramoorthi Swaminathan, Burlingame, CA (US); and Zhongdong Zhao, Bellevue, WA (US)
Assigned to Kronos Bio, Inc., San Mateo, CA (US)
Filed by Kronos Bio, Inc., San Mateo, CA (US)
Filed on Nov. 18, 2022, as Appl. No. 18/057,195.
Application 17/082,595 is a division of application No. 16/413,458, filed on May 15, 2019, granted, now 10,828,299, issued on Nov. 10, 2020.
Application 18/057,195 is a continuation of application No. 17/082,595, filed on Oct. 28, 2020, granted, now 11,517,570.
Application 16/413,458 is a continuation of application No. 15/945,685, filed on Apr. 4, 2018, granted, now 10,342,794, issued on Jul. 9, 2019.
Application 15/945,685 is a continuation of application No. 14/578,973, filed on Dec. 22, 2014, granted, now 9,290,505.
Claims priority of provisional application 61/920,407, filed on Dec. 23, 2013.
Prior Publication US 2023/0158023 A1, May 25, 2023
Int. Cl. A61K 31/4985 (2006.01); A61K 9/00 (2006.01); A61K 31/5377 (2006.01); C07D 487/04 (2006.01)

CPC A61K 31/4985 (2013.01) [A61K 9/0053 (2013.01); A61K 31/5377 (2013.01); C07D 487/04 (2013.01)]

19 Claims

1. A crystalline form of a succinate salt of Compound 2:

wherein the crystalline form is succinate Form II; and

wherein crystalline succinate Form II is characterized by an X-ray powder diffractogram comprising characteristic peaks (° 20) at 7.6°±0.2° 20, 7.9°±0.2° 20, 16.3°±0.2° 20, 22.0°±0.2° 20, and 25.0°±0.2 °20.