US 12,263,159 B2
Fused ring compound having urea structure
Tsuyoshi Nakamura, Tokyo (JP); Mayuko Akiu, Tokyo (JP); Takashi Tsuji, Tokyo (JP); Jun Tanaka, Tokyo (JP); Koji Terayama, Tokyo (JP); Mika Yokoyama, Tokyo (JP); Anthony B. Pinkerton, Rancho Santa Fe, CA (US); and Edward Hampton Sessions, Orlando, FL (US)
Assigned to SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, La Jolla, CA (US)
Filed by Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US)
Filed on Jan. 23, 2024, as Appl. No. 18/420,446.
Application 18/420,446 is a continuation of application No. 17/257,262, granted, now 11,918,568, previously published as PCT/US2019/040595, filed on Jul. 3, 2019.
Claims priority of provisional application 62/694,373, filed on Jul. 5, 2018.
Prior Publication US 2024/0285597 A1, Aug. 29, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4439 (2006.01); A61K 31/422 (2006.01); A61K 31/423 (2006.01); A61K 31/437 (2006.01); A61K 31/443 (2006.01); A61K 31/444 (2006.01); A61K 31/519 (2006.01); A61K 31/538 (2006.01); A61K 31/55 (2006.01); A61K 31/553 (2006.01); A61P 3/04 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 498/08 (2006.01)
CPC A61K 31/4439 (2013.01) [A61K 31/422 (2013.01); A61K 31/423 (2013.01); A61K 31/437 (2013.01); A61K 31/443 (2013.01); A61K 31/444 (2013.01); A61K 31/519 (2013.01); A61K 31/538 (2013.01); A61K 31/55 (2013.01); A61K 31/553 (2013.01); A61P 3/04 (2018.01); A61P 25/28 (2018.01); A61P 27/02 (2018.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 498/08 (2013.01)] 19 Claims
 
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof:

OG Complex Work Unit Chemistry
wherein:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
R1 is a hydrogen atom or a halogen atom;
R2 is a hydrogen atom; a phenyl group or a heteroaryl group optionally substituted with one or more Y; or a C1-C6 alkyl group optionally substituted with a C3-C6 cycloalkyl group;
R3 is a hydrogen atom; a cyano group; a phenyl group or a heteroaryl group each optionally substituted with one or more Y; a C1-C4 alkylcarbonyl group or a C1-C4 alkyl group, each optionally substituted with one or more Z; or —C(═O)—Z;
each Y is independently selected from a C1-C4 alkyl group, a C1-C4 alkoxy group, a phenyl group, a C1-C3 alkylsulfonyl group, a C1-C3 haloalkyl group, a halogen atom, and a C1-C3 alkyl group or a C1-C3 alkoxy group substituted with a C1-C3 alkoxy group;
each Z is independently selected from a C1-C3 alkoxy group, a dioxanyl group, an 8-oxa-3-azabicyclo [3.2.1] octyl group, a C1-C4 alkoxycarbonyl group, and an amino group or a C3-C6 cycloalkylamino group each optionally substituted with one or more W; and
each W is independently selected from a phenyl group, a heteroaryl group, a C1-C3 alkyl group, a C1-C3 alkyl group substituted with phenyl, and a C1-C3 alkyl group substituted with a heteroaryl group.