US 12,263,156 B2
Use of small molecule inhibitors of the BfrB:Bfd interaction in biofilms
Mario Rivera, Baton Rouge, LA (US); Huili Yao, Baton Rouge, LA (US); Richard A. Bunce, Stillwater, OK (US); Baskar Nammalwar, San Diego, CA (US); Krishna Kumar Gnanasekaran, Mississauga (CA); Kate Eshelman, Alexandria, VA (US); Achala N. D. Punchi Hewage, Lawrence, KS (US); Scott Lovell, Shawnee, KS (US); and Anabel Soldano, Baton Rouge, LA (US)
Assigned to Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA (US); The Board of Regents for Oklahoma State University, Lawrence, KS (US); and University of Kansas, Stillwater, OK (US)
Filed by Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA (US); University of Kansas, Lawrence, KS (US); and The Board of Regents for Oklahoma State University, Stillwater, OK (US)
Filed on Oct. 15, 2021, as Appl. No. 17/502,975.
Claims priority of provisional application 63/120,405, filed on Dec. 2, 2020.
Claims priority of provisional application 63/092,571, filed on Oct. 16, 2020.
Prior Publication US 2022/0117937 A1, Apr. 21, 2022
Int. Cl. A61P 31/04 (2006.01); A61K 31/4035 (2006.01)
CPC A61K 31/4035 (2013.01) [A61P 31/04 (2018.01)] 20 Claims
 
1. A method of inhibiting biofilm formation, treating bacteria within a biofilm, or remediating a biofilm in or on a subject, the method comprising administering to the subject an effective amount of a compound according to Formula I

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt and/or a solvate thereof, wherein
R1 is C1-C6 alkoxy, H, OH, or halo;
R2 and R3 are each independently C1-C6 alkoxy, H, or OH;
R4 and R5 are each independently H or halo;
X1 is CH2 or O; and
m is 0, 1, 2, 3, 4, or 5;
provided that:
at least one of R1, R2, and R3 is OH or C1-C6 alkoxy;
when X1 is O, m is not 0; and
when R2 is OH, R1, R3, R4, and R5 are each independently H, and X1 is CH2, then m is not 0; and
wherein the subject is suffering from or at risk of suffering from a bacterial infection.