US 12,263,118 B2
Systems and methods for implantable devices
Paul A. Friedman, Rochester, MN (US); and Samuel J. Asirvatham, Rochester, MN (US)
Assigned to Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed by Mayo Foundation for Medical Education and Research, Rochester, MN (US)
Filed on Jan. 16, 2019, as Appl. No. 16/249,159.
Claims priority of provisional application 62/618,432, filed on Jan. 17, 2018.
Prior Publication US 2019/0216641 A1, Jul. 18, 2019
Int. Cl. A61F 7/12 (2006.01); A61B 5/00 (2006.01); A61B 5/287 (2021.01); A61B 5/361 (2021.01); A61F 5/00 (2006.01); A61F 7/00 (2006.01)
CPC A61F 7/12 (2013.01) [A61B 5/287 (2021.01); A61B 5/361 (2021.01); A61B 5/4836 (2013.01); A61B 5/686 (2013.01); A61F 5/0013 (2013.01); A61F 2005/002 (2013.01); A61F 2007/0093 (2013.01); A61F 2007/126 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An implantable cooling device, the device comprising:
a cooling element configured to contact and cool an oblique pericardial sinus of a patient;
two or more electrodes coupled to the cooling element, the two or more electrodes configured to detect an atrial fibrillation of the patient;
a memory that is capable of storing computer executable instructions; and
a processor that is configured to facilitate execution of the computer executable instructions stored in the memory, wherein the computer executable instructions cause the processor to:
monitor, using the two or more electrodes, a first electrogram of the patient;
after monitoring the first electrogram, apply, using the cooling element, a cooling therapy to the oblique pericardial sinus of the patient;
after or while applying the cooling therapy, monitor, using the two or more electrodes, one or more feedback electrograms;
compare the first electrogram and the one or more feedback electrograms on an amplitude basis;
determine, based on the comparison of the first electrogram and the one or more feedback electrograms, whether to adjust one or more parameters of the cooling therapy and/or to deliver additional cooling therapy from the cooling element;
after or while applying the cooling therapy, monitor a conduction velocity of the patient over time; and
determine, based on the monitoring of the conduction velocity, whether to adjust one or more parameters of the cooling therapy and/or to deliver additional cooling therapy from the cooling element.