US 12,263,004 B2
Cognitive function determination method
Satoshi Yomota, Kyoto (JP); Shin Nakamura, Kyoto (JP); Eiji Ando, Kyoto (JP); Takashi Asada, Tokyo (JP); Hiroko Nakata, Tsukuba (JP); Kazuhiko Uchida, Tsukuba (JP); and Yoshinori Nishimura, Tsukuba (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP); Medical Corporation Sochikai, Tokyo (JP); and MCBI INC., Tsukuba (JP)
Appl. No. 16/628,712
Filed by SHIMADZU CORPORATION, Kyoto (JP); Medical Corporation Sochikai, Tokyo (JP); and MCBI INC., Tsukuba (JP)
PCT Filed Jul. 7, 2017, PCT No. PCT/JP2017/025052
§ 371(c)(1), (2) Date May 11, 2020,
PCT Pub. No. WO2019/008773, PCT Pub. Date Jan. 10, 2019.
Prior Publication US 2020/0268304 A1, Aug. 27, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 5/026 (2006.01)
CPC A61B 5/4064 (2013.01) [A61B 5/0261 (2013.01); A61B 5/483 (2013.01); A61B 5/4884 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A cognitive function determination method comprising:
applying a load including a sensory stimulus to a sensory body of a subject a plurality of times;
measuring, by an optical measurement device, a change in brain activity of the subject when the load is applied in the applying the load the plurality of times, and acquiring measurement data, the change in brain activity of the subject comprises a plurality of change measurements; and
determining, by a processor, a degree of cognitive function of the subject based on comparing the plurality of change measurements with one another such that a significant difference between a first change measurement and a second change measurement indicates that the subject is a non-demented person and no significant difference between the first change measurement and the second change measurement indicates that the subject has cognitive impairment; wherein
an intensity of the sensory stimulus to be applied to the subject in the applying the load the plurality of times is increased each time the stimulus is applied regardless of a subject's response to any previously applied load when the change in brain activity of the subject is measured for determining the degree of cognitive function of the subject.