US 12,262,983 B2
System and method for detecting small blood-tissue barrier disruption
Jinghua Wang, Mason, OH (US); and Lili He, Mason, OH (US)
Assigned to University of Cincinnati, Cincinnati, OH (US); and Children's Hospital Medical Center, Cincinnati, OH (US)
Appl. No. 16/968,231
Filed by UNIVERSITY OF CINCINNATI, Cincinnati, OH (US); and CHILDREN'S HOSPITAL MEDICAL CENTER, Cincinnati, OH (US)
PCT Filed Feb. 7, 2019, PCT No. PCT/US2019/016954
§ 371(c)(1), (2) Date Aug. 7, 2020,
PCT Pub. No. WO2019/157119, PCT Pub. Date Aug. 15, 2019.
Claims priority of provisional application 62/627,369, filed on Feb. 7, 2018.
Prior Publication US 2021/0030301 A1, Feb. 4, 2021
Int. Cl. A61B 5/055 (2006.01); A61B 5/00 (2006.01); G01R 33/56 (2006.01)
CPC A61B 5/055 (2013.01) [A61B 5/0042 (2013.01); G01R 33/5601 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method for detecting blood-tissue barrier breakdown or disruption, the method comprising:
acquiring first image data of a target region of a subject using a magnetic resonance imaging (MRI) apparatus, said MRI apparatus comprising an image reconstruction unit, with a predetermined spatial resolution, wherein the predetermined spatial resolution is less than 3.4 mm3 for a voxel or 2.3 mm2 for a pixel;
administrating exogenous or endogenous tracer into the subject;
acquiring at least one image data of the target region using the MRI apparatus with the predetermined spatial resolution after administration of the tracer;
quantitatively differentiating healthy tissue and pathological tissue with blood-tissue barrier breakdown in the target region using the MRI apparatus based on entire or part of the first image data and the at least one image data; and
visualizing or analyzing the blood-tissue barrier breakdown of pathological tissue with the image reconstruction unit based on the differentiation,
wherein the predetermined spatial resolution is determined by at least one fraction of blood-tissue barrier breakdown in a voxel or pixel.