CPC A61B 5/055 (2013.01) [A61B 5/0042 (2013.01); G01R 33/5601 (2013.01)] | 16 Claims |
1. A method for detecting blood-tissue barrier breakdown or disruption, the method comprising:
acquiring first image data of a target region of a subject using a magnetic resonance imaging (MRI) apparatus, said MRI apparatus comprising an image reconstruction unit, with a predetermined spatial resolution, wherein the predetermined spatial resolution is less than 3.4 mm3 for a voxel or 2.3 mm2 for a pixel;
administrating exogenous or endogenous tracer into the subject;
acquiring at least one image data of the target region using the MRI apparatus with the predetermined spatial resolution after administration of the tracer;
quantitatively differentiating healthy tissue and pathological tissue with blood-tissue barrier breakdown in the target region using the MRI apparatus based on entire or part of the first image data and the at least one image data; and
visualizing or analyzing the blood-tissue barrier breakdown of pathological tissue with the image reconstruction unit based on the differentiation,
wherein the predetermined spatial resolution is determined by at least one fraction of blood-tissue barrier breakdown in a voxel or pixel.
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