US 12,262,982 B2
Systems and methods for detecting small physiological or pathological changes using high resolution magnetic resonance imaging
Jinghua Wang, Mason, OH (US)
Assigned to University of Cincinnati, Cincinnati, OH (US)
Appl. No. 16/648,377
Filed by University of Cincinnati, Cincinnati, OH (US)
PCT Filed Sep. 18, 2018, PCT No. PCT/US2018/051413
§ 371(c)(1), (2) Date Mar. 18, 2020,
PCT Pub. No. WO2019/060258, PCT Pub. Date Mar. 28, 2019.
Claims priority of provisional application 62/560,370, filed on Sep. 19, 2017.
Prior Publication US 2020/0281500 A1, Sep. 10, 2020
Int. Cl. A61B 5/055 (2006.01); G01R 33/48 (2006.01); G01R 33/561 (2006.01)
CPC A61B 5/055 (2013.01) [G01R 33/4818 (2013.01); G01R 33/5611 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A method for obtaining a magnetic resonance imaging (MRI) image of an object, the method comprising:
applying an MRI sequence to a target area in the object;
receiving magnetic resonance (MR) signals from the target area;
acquiring, in one k-space sampling order, a first set of k-space lines based on the MR signals while nuclear spins in the target area are in a transient state;
after an acquisition of the first set of k-space lines, acquiring, in another k-space sampling order, a second set of k-space lines based on the MR signals while the nuclear spins in the target area are in a mixed state of the transient state and the steady-state, the one k-space sampling order being different from the another k-space sampling order;
generating a third set of k-space lines according to Hermitian symmetry of the first set of k-space lines and the second set of k-space lines, the third set of k-space lines comprising one or more k-space lines in a periphery of k-space; and
reconstructing the MRI image based on the first set of k-space lines, the second set of k-space lines, and the third set of k-space lines,
wherein the one k-space sampling order is one of a sequential sampling order, a centric sampling order, an interleave sampling order, a reverse sampling order, a random sampling order, or a hybrid sampling order, and the another k-space sampling order is another of the sequential sampling order, the centric sampling order, the interleave sampling order, the reverse sampling order, the random sampling order, or the hybrid sampling order.