US 12,262,978 B2
Absolute blood volume estimation device and method
Yossi Chait, Longmeadow, MA (US); Joseph Horowitz, Amherst, MA (US); Christopher V. Hollot, East Hampton, MA (US); Hamed Samandari, Mason, OH (US); Michael J. Germain, Hampden, MA (US); and Daniel Schneditz, Graz (AT)
Assigned to University of Massachusetts, Boston, MA (US); Analiza, Inc., Cleveland, OH (US); and Medical University of Graz, Graz (AT)
Filed by University of Massachusetts, Boston, MA (US); Analiza, Inc., Cleveland, OH (US); and Medical University of Graz, Graz (AT)
Filed on Dec. 29, 2023, as Appl. No. 18/400,507.
Application 18/400,507 is a division of application No. 16/617,904, granted, now 11,896,748, previously published as PCT/US2018/035676, filed on Jun. 1, 2018.
Claims priority of provisional application 62/514,322, filed on Jun. 2, 2017.
Prior Publication US 2024/0131239 A1, Apr. 25, 2024
Int. Cl. A61B 5/02 (2006.01); A61B 5/00 (2006.01); A61B 5/0275 (2006.01); A61B 5/145 (2006.01); A61M 1/16 (2006.01); A61M 1/26 (2006.01); A61M 1/36 (2006.01)
CPC A61B 5/02028 (2013.01) [A61B 5/0275 (2013.01); A61B 5/14535 (2013.01); A61B 5/6866 (2013.01); A61M 1/1613 (2014.02); A61M 1/267 (2014.02); A61M 1/361 (2014.02); A61M 2205/3389 (2013.01); A61M 2205/50 (2013.01); A61M 2205/52 (2013.01); A61M 2230/20 (2013.01); A61M 2230/207 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for estimating absolute blood volume at a dialysis machine, the method comprising:
injecting, using a pump, a predetermined volume of indicator liquid into a blood stream of a patient;
obtaining, via a sensor, a series of measurements of hemoconcentration of at least one blood characteristic of the patient over a time period, the series of measurements including a hemoconcentration at a dilution test time during the time period, and the series of measurements of hemoconcentration based on blood volume compared to the predetermined volume of indicator liquid;
estimating parameters for a physiological model based on the series of measurements, the parameters including the hemoconcentration at the dilution test time, a volume of a first compartment and a volume of a second compartment at the dilution test time and at an dilution injection time of the time period;
determining an absolute blood volume of the patient at the dilution test time using the physiological model and the series of measurements of hemoconcentration; and
outputting the absolute blood volume on a display portion of the dialysis machine.