US 11,942,313 B2
Mass spectrometer and mass spectrometry method
Yusuke Tagawa, Kyoto (JP); and Yuki Ishikawa, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Appl. No. 17/601,456
Filed by SHIMADZU CORPORATION, Kyoto (JP)
PCT Filed May 8, 2019, PCT No. PCT/JP2019/018334
§ 371(c)(1), (2) Date Oct. 5, 2021,
PCT Pub. No. WO2020/225863, PCT Pub. Date Nov. 12, 2020.
Prior Publication US 2022/0199382 A1, Jun. 23, 2022
Int. Cl. H01J 49/00 (2006.01); G01N 27/623 (2021.01); H01J 49/04 (2006.01)
CPC H01J 49/0031 (2013.01) [G01N 27/623 (2021.01); H01J 49/0009 (2013.01); H01J 49/0431 (2013.01); H01J 49/0036 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A mass spectrometry method using a mass spectrometer including an ion source using an atmospheric pressure ionization method for ionizing a component contained in a liquid sample, the method comprising, to optimize N parameters that affect ionization efficiency in the ion source, N being an integer of 2 or more:
a measurement execution step of repeatedly executing measurement on a sample containing a target component while changing a value of each of the N parameters or a value set of M parameters among the N parameters in a plurality of stages, M being an integer smaller than N; and
a parameter value search step of sequentially finding an optimum value of each of the N parameters or an optimum value set of the M parameters based on a measurement result in the measurement execution step, wherein
in the measurement execution step, a value of at least one parameter whose physical quantity is temperature among the N parameters or a value set of the M parameters including the at least one parameter is changed prior to all parameters whose physical quantities are other than temperature among the N parameters, and
in the parameter value search step, the at least one parameter whose physical quantity is temperature is optimized prior to all the parameters whose physical quantities are other than temperature.