US 11,939,402 B2
Antifungal peptides, compounds including the same, and methods of use thereof
Gregory R. Wiedman, New Milford, NJ (US); Robert J. Tancer, Montville, NJ (US); and Chaoyang Xue, Livingston, NJ (US)
Assigned to Seton Hall University, South Orange, NJ (US); and Rutgers, The State University of New Jersey, New Brunswick, NJ (US)
Filed by Seton Hall University, South Orange, NJ (US); and Rutgers, The State University of New Jersey, New Brunswick, NJ (US)
Filed on Mar. 29, 2023, as Appl. No. 18/128,062.
Claims priority of provisional application 63/324,909, filed on Mar. 29, 2022.
Prior Publication US 2023/0312650 A1, Oct. 5, 2023
Int. Cl. C07K 7/00 (2006.01); A61K 38/12 (2006.01); A61P 31/10 (2006.01); C07K 7/08 (2006.01)
CPC C07K 7/08 (2013.01) [A61K 38/12 (2013.01); A61P 31/10 (2018.01)] 22 Claims
 
1. An antifungal peptide targeting a P4-ATPase function peptide, the antifungal peptide having the following formula:

OG Complex Work Unit Chemistry
wherein,
R1 is —C(O)RA, wherein RA is a C1 to C14 alkyl group,
R2 is an alkyl group, a hydroxyl group, a phenol group, a phenyl group,
or an indole group,
R3 is an alkyl group, an alkylamine group, a diamine group, or an indole group,
R4 is a hydrogen, an alkyl group, a diamine group, or alkylamine group, and
R5 is alkyl group, a alkylamide group, or a phenyl group having a hydroxyl substituent.