US 11,938,135 B2
Compositions and methods for treating vascular Ehlers Danlos syndrome and associated disorders
Harry C. Dietz, Towson, MD (US); Caitlin J. Bowen, Baltimore, MD (US); and Juan Francisco Calderon Giadrosic, Santiago (CL)
Assigned to The Johns Hopkins University, Baltimore, MD (US)
Appl. No. 17/286,414
Filed by The Johns Hopkins University, Baltimore, MD (US)
PCT Filed Oct. 16, 2019, PCT No. PCT/US2019/056616
§ 371(c)(1), (2) Date Apr. 16, 2021,
PCT Pub. No. WO2020/081741, PCT Pub. Date Apr. 23, 2020.
Claims priority of provisional application 62/838,049, filed on Apr. 24, 2019.
Claims priority of provisional application 62/747,587, filed on Oct. 18, 2018.
Claims priority of provisional application 62/746,524, filed on Oct. 16, 2018.
Prior Publication US 2021/0386740 A1, Dec. 16, 2021
Int. Cl. A61K 31/517 (2006.01); A61K 31/353 (2006.01); A61K 31/407 (2006.01); A61K 31/4184 (2006.01); A61K 31/436 (2006.01); A61K 31/4523 (2006.01); A61K 31/4545 (2006.01); A61K 31/502 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 31/537 (2006.01); A61K 31/58 (2006.01); A61K 31/69 (2006.01); A61K 39/395 (2006.01); A61P 9/14 (2006.01)
CPC A61K 31/517 (2013.01) [A61K 31/353 (2013.01); A61K 31/407 (2013.01); A61K 31/4184 (2013.01); A61K 31/436 (2013.01); A61K 31/4523 (2013.01); A61K 31/4545 (2013.01); A61K 31/502 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 31/537 (2013.01); A61K 31/58 (2013.01); A61K 31/69 (2013.01); A61K 39/3955 (2013.01); A61P 9/14 (2018.01)] 30 Claims
 
1. A method of treating vascular Ehlers-Danlos Syndrome (vEDS) in a subject in need thereof, the method comprising:
administering to the subject an effective amount of an agent selected from ruboxistaurin, enzastaurin, sotrastaurin, or a pharmaceutically acceptable salt thereof.