US 12,260,944 B2
Drug dosage determination devices and methods
Geraint Iwan Davies, Basel (CH); David Elfant, Basel (CH); and Martin Jenkins, Southampton (GB)
Assigned to HOFFMANN-LA-ROCHE INC., Little Falls, NJ (US)
Appl. No. 17/767,842
Filed by Hoffmann-La Roche Inc., Little Falls, NJ (US)
PCT Filed Oct. 7, 2020, PCT No. PCT/EP2020/078139
§ 371(c)(1), (2) Date Apr. 8, 2022,
PCT Pub. No. WO2021/069504, PCT Pub. Date Apr. 15, 2021.
Claims priority of application No. 2019903839 (AU), filed on Oct. 11, 2019; and application No. 19202828 (EP), filed on Oct. 11, 2019.
Prior Publication US 2023/0145898 A1, May 11, 2023
Int. Cl. G16H 20/10 (2018.01)
CPC G16H 20/10 (2018.01) 14 Claims
OG exemplary drawing
 
1. A method of treating a subject with a drug comprising:
(i) determining an administration regimen of the drug to a subject, by a processor:
receiving the value of at least one parameter associated with the subject;
determining the amount of drug (At) to be administered to the subject per elemental period of time (t) based at least in part on the value of the at least one parameter associated with the subject, wherein the drug is available in at least two different dosage forms (D1, D2) that differ by the total amount of drug and/or the drug concentration in a dose of the dosage form, wherein a dosage form is a pharmaceutical formulation of the drug associated with a total amount of the drug and a concentration of the drug in a dose, and wherein at least one of the dosage forms is a single use dosage form;
computing all minimal combinations (At [D1,D2, D1D2]) of the at least two different dosage forms that can be used to achieve the amount of drug (At) to be administered to the subject, wherein a minimal combination is a combination that reaches or exceeds the amount of drug (At) to be administered to the subject by using the minimum number of doses of each dosage form in a combination of dosage forms (D1, D2, D1D2);
selecting a subset of the combinations (At [D1,D2, D1D2]) that satisfy at least a first criterion and a second criterion, wherein the first and second criteria are selected from:
a criterion that applies to the value of the total wastage associated with the combinations, wherein the wastage associated with a combination of dosage forms (Wt [D1,D2, D1D2]; Wn1t [D1,D2, D1D2]; Wn2t [D1,D2, D1D2]) is the difference between the total amount of drug in the combination of dosage forms and the amount of drug (At, An1t, An2t) to be administered to the subject,
a criterion applies to the value of the total number of physical administrations steps associated with the combinations, and
a criterion that applies to the total number of physical preparative steps associated with the combinations; and
outputting at a user interface the selected subset of combinations as the optimal administration regimen(s) for the subject; and
(ii) treating the subject with one of said optimal administration regimen(s).