US 12,259,372 B2
Method of cleaning liquid chromatographic system and liquid chromatographic system
Keisuke Ogawa, Columbia, MD (US); Andy Sasaki, Columbia, MD (US); Kerry Hill, Columbia, MD (US); and Timothy Lee, Columbia, MD (US)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Filed by SHIMADZU CORPORATION, Kyoto (JP)
Filed on Oct. 23, 2022, as Appl. No. 17/971,605.
Claims priority of provisional application 63/273,182, filed on Oct. 29, 2021.
Prior Publication US 2023/0136050 A1, May 4, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 30/32 (2006.01); B01D 15/14 (2006.01); B01D 15/16 (2006.01); B01D 15/18 (2006.01); B01D 15/42 (2006.01); B08B 9/032 (2006.01); G01N 30/20 (2006.01); G01N 30/46 (2006.01); G01N 30/02 (2006.01)
CPC G01N 30/46 (2013.01) [B01D 15/14 (2013.01); B01D 15/163 (2013.01); B01D 15/1864 (2013.01); B01D 15/424 (2013.01); B08B 9/0325 (2013.01); G01N 30/20 (2013.01); G01N 30/32 (2013.01); B08B 2209/032 (2013.01); G01N 2030/027 (2013.01); G01N 2030/326 (2013.01); G01N 2030/328 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method of cleaning a liquid chromatographic system,
the liquid chromatographic system including
a first column and a second column for separation of a sample,
a needle that takes a sample to be injected into the first column and the second column,
an injection valve portion to which the first column and the second column are connected, the injection valve portion including a first injection valve connected to the first column and a second injection valve connected to the second column,
a first pump that supplies an eluent to the first injection valve,
a second pump that supplies an eluent to the second injection valve,
a first analysis flow path constructed such that the eluent flows from the first injection valve toward the first column,
a second analysis flow path constructed such that the eluent flows from the second injection valve toward the second column, and
a selector valve connected to the first column and the second column, the selector valve switching an object to be connected to a detector between the first analysis flow path and the second analysis flow path, the method comprising:
setting a condition for feeding a cleaning solution or a blank sample to the selector valve;
cleaning the first analysis flow path by feeding the cleaning solution or the blank sample while a first flow path through which the eluent flows from the first injection valve to the first column via the needle is set; and
cleaning the first analysis flow path by feeding the cleaning solution or the blank sample while a second flow path through which the eluent flows from the first injection valve to the first column not via the needle is set.