	US 12,259,352 B2
	Membrane enhanced sensors
Jason Charles Heikenfeld, Cincinnati, OH (US); Yuchan Yuan, Cincinnati, OH (US); Madeleine Debrosse, Cincinnati, OH (US); and Michael Charles Brothers, Lebanon, OH (US)
Assigned to University of Cincinnati, Cincinnati, OH (US)
Appl. No. 17/053,007
Filed by University Of Cincinnati, Cincinnati, OH (US)
PCT Filed May 3, 2019, PCT No. PCT/US2019/030599 § 371(c)(1), (2) Date Nov. 4, 2020, PCT Pub. No. WO2019/213520, PCT Pub. Date Nov. 7, 2019.
Claims priority of provisional application 62/666,921, filed on May 4, 2018.
Prior Publication US 2021/0364464 A1, Nov. 25, 2021
Int. Cl. G01N 27/333 (2006.01); A61B 5/145 (2006.01); A61B 5/1468 (2006.01); G01N 1/40 (2006.01); G01N 21/01 (2006.01)

CPC G01N 27/333 (2013.01) [A61B 5/14517 (2013.01); A61B 5/1468 (2013.01); G01N 1/4005 (2013.01); G01N 21/01 (2013.01)]

36 Claims

1. A sensing device, comprising:

one or more sensors configured to measure a characteristic of an analyte in a sample;

a sample solution that contains the analyte and one or more interfering solutes, wherein the interfering solute reduces a performance characteristic of the one or more sensors;

a sensor solution in fluidic communication with the one or more sensors; and

a hydrophobic barrier that separates the sample solution from the one or more sensors, wherein the hydrophobic barrier is permeable to the analyte and impermeable to the interfering solute, and wherein the hydrophobic barrier is in fluidic communication with the sample solution and the sensor solution; and

wherein the one or more sensors is an electrochemical aptamer sensor with an attached redox couple.